OrthoNet

Chondrosarcoma

- malignant tumor occurring btw 40-70 yrs
- commonly found in pelvis, proximal femur, scapula & proximal humerus

Signs & Symptoms:
- pain localized to region of tumor of relatively long duration
- tenderness, localized swelling, palpable mass, antalgic gait

Xrays:
- cortical thickening, endosteal scalloping & fusiform expansion of bone
- matrix calcification in stippled or ring-like pattern
- soft tissue extension may be seen with larger tumors
- overlying cortex thinned & expanded

Histology:
- lobulated containing chondrocytes lying within lacunae separated by abundant hyaline matrix
- cells show mild-moderate nuclear pleomorphism & binucleated
- tumor infiltration of marrow spaces
- low grade chondrosarcoma difficult to distinguish from enchondroma

Treatment:
- wide excision (amputation vs limb salvage)
- not responsive to chemotherapy or radiation