OrthoNet

Malignant Lymphoma

- 1o malignant lymphoma of bone = tumor arising within bone & remaining localized at the original site without extrasseous involvement for at least 6 months
- usu presents in 3rd decade involving distal femur or proximal femur

Signs & Symptoms:
- pain & swelling at tumor site +/- tender soft tissue mass
- usu no constitutional symptoms

Xrays:
- poorly marginated, destructive permeative lesion in diaphysis of long bones
- may be lytic, sclerotic or a mixture of both
- periosteal reaction with cortical thickening

Histology:
- diffuse infiltration of round lymphoid cells varying from small - large cells which have grooved nuclei & conspicuous nucleoli
- areas of spindle cell proliferation with fibrosis
- usu large B-cell type lymphoctyes

Treatment:
- radiation & chemotherapy
- 5 yr survival = 20-50% depending on presence of extraosseous lesions