Malignant Fibrous Histiocytoma (MFH)

MFH
Malignant Fibrous Histiocytoma (MFH of bone)

– malignant tumor occurring in metadiaphyseal region of long bones of adults
– thought to be derived from fibroblasts

Signs & Symptoms:
– pain & swelling associated with tender mass usu present for at least 6 mos

Xrays:
– lytic lesions with cortical destruction with minimal periosteal reaction
– may see soft tissue mass

Histology:
– spindle & histiocytoid cells with scattered multinucleated giant cells & lipid-laden histiocytes
– spindle cells arranged in storiform or cartwheel pattern where they form fascicles that intersect in a central hypocellular area
– varying degree of cell pleomorphism

Treatment:
– wide excision (amputation vs limb salvage)
– benefits of chemotherapy inconclusive
– radiation used postoperatively
– 5 yr survival = 50%