Nonossifiying Fibroma (NOF)
– metaphyseal fibrous lesion of long bones (esp around knee) in children
– advanced form of fibrous cortical defect because no longer confined to cortex but extend into medullary canal
– usu ossify by 3rd decade
Signs & Symptoms:
– painful lesion
– pathological #
– clearly demarcated, eccentric, multilocular expansile lesions with scalloped, sclerotic margins
– bilateral or multiple lesions common
– cortex may be attenuated in areas adjacent to lesion
– spindle cells arranged in storiform pattern
– whorls of connective tissue interspersed with multinucleated giant cells & lipid-laden macrophages (foam cells)
– self-limited lesions – observation
– large lesions that encompass > 50% bone diameter may require curettage & bone grafting (impending pathologic #)
Leave a ReplyWant to join the discussion?
Feel free to contribute!